An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Supercritical carbon dioxide (scCO2) application in the pharmaceutical industry is still undeveloped regardless of significant research interests this processing medium shown last decades. ScCO2 technologies can improve drug solubility, bioavailability, and therapeutic effect. These lead to development new formulations that will contribute a decrease dose, medication frequency, increase patients' well-being. Considering price high-pressure equipment society's growing need for cleaner production safer products, it expected symbiosis between supercritical fluid happen soon. Therefore, review was focused on latest contributions scCO2 field. The main aim bring these closer specialists. For purpose, most commonly used were explained discussed: preparation solid dispersions, polymer impregnation with drugs, micro/nanoparticle using scCO2.